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Part 1: Document Description
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Citation |
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Title: |
Sitia L. et al. Cells, 2021, doi:10.3390/cells10020328 |
Identification Number: |
doi:10.13130/RD_UNIMI/SKRLH0 |
Distributor: |
UNIMI Dataverse |
Date of Distribution: |
2021-02-15 |
Version: |
1 |
Bibliographic Citation: |
Mazzucchelli, Serena, 2021, "Sitia L. et al. Cells, 2021, doi:10.3390/cells10020328", https://doi.org/10.13130/RD_UNIMI/SKRLH0, UNIMI Dataverse, V1, UNF:6:8zE4cXNoQVCZc+paF4XK3A== [fileUNF] |
Citation |
|
Title: |
Sitia L. et al. Cells, 2021, doi:10.3390/cells10020328 |
Identification Number: |
doi:10.13130/RD_UNIMI/SKRLH0 |
Authoring Entity: |
Mazzucchelli, Serena (University of Milan) |
Distributor: |
UNIMI Dataverse |
Access Authority: |
Mazzucchelli, Serena |
Depositor: |
Mazzucchelli, Serena |
Date of Deposit: |
2021-02-03 |
Study Scope |
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Keywords: |
Medicine, Health and Life Sciences |
Abstract: |
This dataset contains raw data from Sitia, L.; Bonizzi, A.; Mazzucchelli, S.; Negri, S.; Sottani, C.; Grignani, E.; Rizzuto, M.A.; Prosperi, D.; Sorren-tino, L.; Morasso, C.; et al. Selective targeting of Cancer-Associated Fi-broblasts by engineered H-ferritin nanocages loaded with navitoclax. Cells 2021, 10.3390/cells10020328 |
Methodology and Processing |
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Sources Statement |
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Data Access |
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Notes: |
CC0 Waiver |
Other Study Description Materials |
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Related Publications |
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Citation |
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Bibliographic Citation: |
Sitia, L.; Bonizzi, A.; Mazzucchelli, S.; Negri, S.; Sottani, C.; Grignani, E.; Rizzuto, M.A.; Prosperi, D.; Sorren-tino, L.; Morasso, C.; et al. Selective targeting of Cancer-Associated Fi-broblasts by engineered H-ferritin nanocages loaded with navitoclax. Cells 2021, doi:10.3390/cells10020328 |
File Description--f5968 |
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File: Binding with HFn-FAP.tab |
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Notes: |
UNF:6:F0XTs/fNeIcYC7XjfnVIpQ== |
File Description--f5971 |
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File: Biodistribution data.tab |
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Notes: |
UNF:6:H5sRVSomBoSpQtxVMkx3Hg== |
File Description--f5965 |
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File: FAP and TfR1 expression.tab |
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Notes: |
UNF:6:ygdt6NwR+HoL1m2n7YcLyg== |
File Description--f5970 |
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File: HNav activity and stability.tab |
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Notes: |
UNF:6:cv7+vVLJuRGNT+SghR4BCA== |
File Description--f5972 |
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File: HNAV and HNav-FAP loading and recoveries.tab |
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Notes: |
UNF:6:bijeiGLwnfaZc8jJMdF8mQ== |
File Description--f5967 |
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File: MTS Control HFn HFAP and CuSO4 .tab |
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Notes: |
UNF:6:bvqx1JZqvc3QQW0e0+va1Q== |
File Description--f5969 |
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File: MTS Nav HNav and HNav-FAP activity.tab |
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Notes: |
UNF:6:kc1d+G6/FerIyPl7AEvUlA== |
File Description--f5966 |
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File: Nav uptake .tab |
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Notes: |
UNF:6:5aPQ+FnDVFw9UBZOqJCKHQ== |
List of Variables: |
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Variables |
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ContributionofHFn-FAPinbindingFAP+(CAFsandHMfs)versusFAP-(MDA-MB-231)cells |
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f5968 Location: |
Variable Format: character Notes: UNF:6:uj1cQ+IMQgl9wmrYoV0HpQ== |
f5968 Location: |
Variable Format: character Notes: UNF:6:476BZY2MDXn5alA73fWUOA== |
f5968 Location: |
Variable Format: character Notes: UNF:6:uucm8prZfoj89zdqMxTCTA== |
f5968 Location: |
Variable Format: character Notes: UNF:6:1VWQknjvfFilu6Xd/WAvrA== |
f5968 Location: |
Variable Format: character Notes: UNF:6:Io6ONHl3B42O9hXHt8fk7Q== |
f5968 Location: |
Variable Format: character Notes: UNF:6:EIf5k45/qmuK1/oLlBPuzA== |
f5968 Location: |
Variable Format: character Notes: UNF:6:jCZk+ZQz2DRFW+y74jlLzg== |
Quantificationofthefluorescentsignalmeasuredinthetumorsbyexvivoimaging,expressedasaverageradiantefficiency |
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f5971 Location: |
Variable Format: character Notes: UNF:6:cmRMQ/KTq4bihY6utIWSnw== |
f5971 Location: |
Variable Format: character Notes: UNF:6:Z6bwLle5wSYA6nR0AI+8dg== |
f5971 Location: |
Variable Format: character Notes: UNF:6:OOgg4gRixlqz3c6lqOhzPg== |
f5971 Location: |
Variable Format: character Notes: UNF:6:p4+YGA9I0Hs98+32q/8RuQ== |
f5971 Location: |
Variable Format: character Notes: UNF:6:XlHtFDT5qaH0Wr2e15H5cQ== |
f5965 Location: |
Variable Format: character Notes: UNF:6:e865OMVZTbg+kH5dTKR1SQ== |
f5965 Location: |
Summary Statistics: StDev 1.6350025484179915; Max. 62.54; Valid 3.0; Mean 60.903333333333336; Min. 59.27 Variable Format: numeric Notes: UNF:6:yOH2o7xTwMnR2AkMaYLioQ== |
f5965 Location: |
Summary Statistics: Valid 3.0; Max. 1.97; Mean 1.1233333333333333; Min. 0.28; StDev 0.8450049309520823 Variable Format: numeric Notes: UNF:6:b2gj9qZI8iLpboLwUz83tQ== |
f5965 Location: |
Summary Statistics: Max. 98.23; Min. 50.62; Valid 9.0; Mean 78.87; StDev 20.221194326745394 Variable Format: numeric Notes: UNF:6:/+Z5o/ucVcPvRmgrigIhIw== |
f5965 Location: |
Summary Statistics: Mean 0.305; Max. 0.7; Min. 0.07; StDev 0.3011644069275119; Valid 4.0; Variable Format: numeric Notes: UNF:6:YdK90e00Y6GvJdfVCF1o2g== |
f5965 Location: |
Summary Statistics: Valid 0.0; Min. NaN; StDev NaN; Mean NaN; Max. NaN; Variable Format: numeric Notes: UNF:6:6kmqn29s8tU9RU5ii6WjOQ== |
f5965 Location: |
Summary Statistics: Max. NaN; StDev NaN; Min. NaN; Mean NaN; Valid 0.0 Variable Format: numeric Notes: UNF:6:6kmqn29s8tU9RU5ii6WjOQ== |
f5970 Location: |
Variable Format: character Notes: UNF:6:XcA8E0lCkptYsOsM0qQV4Q== |
f5970 Location: |
Variable Format: character Notes: UNF:6:LEPSXjVKoXH1Wz0YoHzquA== |
f5970 Location: |
Summary Statistics: Max. 199.0; Valid 112.0; Mean 45.23214285714286; StDev 26.26064165003018; Min. 12.0 Variable Format: numeric Notes: UNF:6:SW3RXntlOrrk7W2/7V8RTw== |
f5970 Location: |
Summary Statistics: Valid 112.0; Max. 13.0; Mean 2.1875; Min. 0.0; StDev 2.9209749390562383 Variable Format: numeric Notes: UNF:6:ZsLrcDa2/wDx7nmRKXnzrg== |
f5970 Location: |
Summary Statistics: Min. 0.0; Valid 112.0; Mean 5.467761553980776; Max. 34.375; StDev 7.327715831610583 Variable Format: numeric Notes: UNF:6:ydlxrTib0jGBSaxdyX+CqA== |
f5972 Location: |
Variable Format: character Notes: UNF:6:m2qyp8Y6Eikz9gFc078R1g== |
f5972 Location: |
Variable Format: character Notes: UNF:6:j369Q9Q6Lf+kToc9Xg4Erw== |
f5972 Location: |
Variable Format: character Notes: UNF:6:FphAXsR2vMxQtuyvXCzizQ== |
f5972 Location: |
Variable Format: character Notes: UNF:6:fQJok/IEV8Eg9FYiu2UK2Q== |
f5972 Location: |
Variable Format: character Notes: UNF:6:rTd/cY1N1dQzw7uZQtrbig== |
f5972 Location: |
Variable Format: character Notes: UNF:6:u6m1zSJXVZo2LV9Et61SXw== |
f5972 Location: |
Variable Format: character Notes: UNF:6:S5opGAGLHxtm4ne1WqlSiQ== |
f5972 Location: |
Variable Format: character Notes: UNF:6:0Waspe0sflzn5Nk6tAgDBQ== |
f5972 Location: |
Variable Format: character Notes: UNF:6:dsn8MHl8vgJ6dO4/EjKbDw== |
f5972 Location: |
Summary Statistics: StDev NaN; Valid 0.0; Min. NaN; Max. NaN; Mean NaN Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Min. NaN; Max. NaN; Mean NaN; StDev NaN; Valid 0.0; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Mean NaN; Max. NaN; Min. NaN; StDev NaN; Valid 0.0 Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Max. NaN; Mean NaN; Valid 0.0; Min. NaN; StDev NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Mean NaN; Min. NaN; Valid 0.0; Max. NaN; StDev NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Valid 0.0; Min. NaN; Max. NaN; Mean NaN; StDev NaN Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Valid 0.0; Mean NaN; Max. NaN; StDev NaN; Min. NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: StDev NaN; Mean NaN; Valid 0.0; Max. NaN; Min. NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Min. NaN; Max. NaN; Mean NaN; Valid 0.0; StDev NaN Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Min. NaN; Valid 0.0; Mean NaN; StDev NaN; Max. NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: StDev NaN; Valid 0.0; Mean NaN; Min. NaN; Max. NaN Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: StDev NaN; Mean NaN; Min. NaN; Valid 0.0; Max. NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Mean NaN; Max. NaN; Min. NaN; StDev NaN; Valid 0.0; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Max. NaN; Valid 0.0; Min. NaN; Mean NaN; StDev NaN Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Min. NaN; Valid 0.0; Max. NaN; Mean NaN; StDev NaN Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: Max. NaN; Mean NaN; Min. NaN; Valid 0.0; StDev NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
f5972 Location: |
Summary Statistics: StDev NaN; Valid 0.0; Min. NaN; Mean NaN; Max. NaN; Variable Format: numeric Notes: UNF:6:6W9cQ9bpMTWkc7U47ZEHLg== |
CellviabilityupontreatmentwithHFnandHFnFAPtoexcludeanyactiveroleofFAPtargetingwithfunctionalizednanovectorsincubatedinHMfsfor24h |
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f5967 Location: |
Summary Statistics: Valid 0.0; StDev NaN; Mean NaN; Max. NaN; Min. NaN Variable Format: numeric Notes: UNF:6:yQIyWGuAH5VYp28vlj7M2A== |
f5967 Location: |
Variable Format: character Notes: UNF:6:sGYwLScIsqC185eJhAQRSQ== |
f5967 Location: |
Variable Format: character Notes: UNF:6:dDCQXelvx/qXLGdWs4885Q== |
f5967 Location: |
Summary Statistics: Min. NaN; Max. NaN; StDev NaN; Mean NaN; Valid 0.0 Variable Format: numeric Notes: UNF:6:yQIyWGuAH5VYp28vlj7M2A== |
f5967 Location: |
Variable Format: character Notes: UNF:6:Mrs7ewyv1/gyUncCLf4FBQ== |
f5967 Location: |
Variable Format: character Notes: UNF:6:J9ZtxkRNB6DcSGo3jJMQBA== |
f5969 Location: |
Summary Statistics: StDev NaN; Max. NaN; Mean NaN; Min. NaN; Valid 0.0 Variable Format: numeric Notes: UNF:6:YNqjpffb+iAPjIKEDs9bQg== |
f5969 Location: |
Variable Format: character Notes: UNF:6:HkIy8oe5SGl+jgJDoW8mFw== |
f5969 Location: |
Variable Format: character Notes: UNF:6:L85UGXL5l4KVkOKoRBw9qw== |
f5969 Location: |
Summary Statistics: Valid 4.0; Mean 110.44275499999999; StDev 17.35380214735184; Min. 89.14822; Max. 128.128 Variable Format: numeric Notes: UNF:6:AcsuxeESKdsD4MVPQva3gg== |
f5969 Location: |
Summary Statistics: Valid 4.0; Max. 130.5101; Min. 90.44755; StDev 19.68729018141632; Mean 112.1571125 Variable Format: numeric Notes: UNF:6:1ScUhzjRd9tQhqRfuDOz9A== |
f5969 Location: |
Summary Statistics: Min. 91.38595; Valid 4.0; Mean 109.7930625; StDev 15.805127479575265; Max. 123.436; Variable Format: numeric Notes: UNF:6:ew+XHeksmCsaC2lIWpyCYw== |
f5969 Location: |
Summary Statistics: Max. 122.0645; Valid 4.0; StDev 17.780931424029085; Min. 83.95091; Mean 106.40037749999999 Variable Format: numeric Notes: UNF:6:QLovpmmVh7wGBI4VpzhC5Q== |
f5969 Location: |
Summary Statistics: Valid 4.0; Max. 113.4023; StDev 12.590720801850791; Mean 102.0512425; Min. 86.33301 Variable Format: numeric Notes: UNF:6:yz1ApqlBat55s524lFhjSA== |
f5969 Location: |
Variable Format: character Notes: UNF:6:unIgZbgitFTlRV5pX6oESA== |
f5969 Location: |
Summary Statistics: StDev 11.509889644525998; Min. 105.1732; Mean 121.017775; Valid 4.0; Max. 132.026; Variable Format: numeric Notes: UNF:6:P9+z3rUYifi+zhFSrcOH5g== |
f5969 Location: |
Summary Statistics: Max. 133.975; Mean 119.068815; StDev 16.769829922281062; Min. 95.13956; Valid 4.0 Variable Format: numeric Notes: UNF:6:YDikeiYlymzQ+ZOZPLoofA== |
f5969 Location: |
Summary Statistics: StDev 20.167788457130506; Max. 127.6227; Valid 4.0; Min. 85.25024; Mean 114.990385 Variable Format: numeric Notes: UNF:6:UGwGFUm76xwNZtH8fSXYPw== |
f5969 Location: |
Summary Statistics: Min. 81.92974; Max. 123.1473; StDev 19.43184426150968; Valid 4.0; Mean 110.316435 Variable Format: numeric Notes: UNF:6:lttUip6bywAjkbUorPV3wQ== |
f5969 Location: |
Summary Statistics: Max. 121.8479; Valid 4.0; StDev 16.71555344271516; Mean 109.05318; Min. 85.82772 Variable Format: numeric Notes: UNF:6:o46cKZWMjKvkx9al6ffVYw== |
f5969 Location: |
Variable Format: character Notes: UNF:6:6VHcS9lbNd0P4x3/d+/0Hw== |
f5969 Location: |
Summary Statistics: Max. 124.5188; Mean 109.9013625; Valid 4.0; StDev 18.19481901610891; Min. 84.74495 Variable Format: numeric Notes: UNF:6:yiMR0zs16hDjbt36SDz4gA== |
f5969 Location: |
Summary Statistics: StDev 21.092385065079764; Valid 4.0; Mean 114.55728; Min. 83.44562; Max. 130.1492 Variable Format: numeric Notes: UNF:6:APUtS1oqjaiidfYgTe/4zw== |
f5969 Location: |
Summary Statistics: Valid 4.0; Min. 84.52839; Max. 135.2743; Mean 115.0445225; StDev 21.644321557320566; Variable Format: numeric Notes: UNF:6:rh7PMX9UGvjptLYJlBaFmw== |
f5969 Location: |
Summary Statistics: Min. 76.94899; Max. 124.9519; Valid 4.0; Mean 107.2304975; StDev 21.098425878803337 Variable Format: numeric Notes: UNF:6:RwKxjIgZD8dCsHjuxHf42g== |
f5969 Location: |
Summary Statistics: Max. 103.1521; Mean 91.31378000000001; StDev 13.078158848431231; Min. 77.45428; Valid 4.0 Variable Format: numeric Notes: UNF:6:RP5Kh9lQsnqhjL2Y54ItlA== |
CellularuptakeofNav,HnavandHnav-FAPincubatedfor1hinHMfsandMDA-MB-231quantifiedbyUPLCMS/MS |
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f5966 Location: |
Variable Format: character Notes: UNF:6:XN1WCXrRmc0A7ws926RPVw== |
f5966 Location: |
Variable Format: character Notes: UNF:6:FifVUibDj0Tga7oMbBtakQ== |
f5966 Location: |
Variable Format: character Notes: UNF:6:xLtvIHrwnBiZrNdc3NtJHA== |
f5966 Location: |
Variable Format: character Notes: UNF:6:LOkj9hmUjU1GFr9VoeZUAA== |
f5966 Location: |
Summary Statistics: Max. NaN; StDev NaN; Valid 0.0; Mean NaN; Min. NaN; Variable Format: numeric Notes: UNF:6:lMEe08PHMBatuSQWNSZ44Q== |
f5966 Location: |
Summary Statistics: Mean NaN; StDev NaN; Max. NaN; Min. NaN; Valid 0.0; Variable Format: numeric Notes: UNF:6:lMEe08PHMBatuSQWNSZ44Q== |
f5966 Location: |
Summary Statistics: Mean NaN; StDev NaN; Valid 0.0; Max. NaN; Min. NaN; Variable Format: numeric Notes: UNF:6:lMEe08PHMBatuSQWNSZ44Q== |
f5966 Location: |
Summary Statistics: Mean NaN; Max. NaN; Valid 0.0; Min. NaN; StDev NaN Variable Format: numeric Notes: UNF:6:lMEe08PHMBatuSQWNSZ44Q== |
f5966 Location: |
Summary Statistics: Valid 0.0; Max. NaN; StDev NaN; Mean NaN; Min. NaN Variable Format: numeric Notes: UNF:6:lMEe08PHMBatuSQWNSZ44Q== |