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Part 1: Document Description
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Citation |
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Title: |
Replication Data for Proteomic screening identifies megakaryocyte-derived PF4/Cxcl4 as a critical driver of myelofibrosis |
Identification Number: |
doi:10.13130/RD_UNIMI/RI3IDJ |
Distributor: |
UNIMI Dataverse |
Date of Distribution: |
2023-05-30 |
Version: |
2 |
Bibliographic Citation: |
Capitanio, Daniele, 2023, "Replication Data for Proteomic screening identifies megakaryocyte-derived PF4/Cxcl4 as a critical driver of myelofibrosis", https://doi.org/10.13130/RD_UNIMI/RI3IDJ, UNIMI Dataverse, V2, UNF:6:EIynqsgx5iLtwL7IRdTYTg== [fileUNF] |
Citation |
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Title: |
Replication Data for Proteomic screening identifies megakaryocyte-derived PF4/Cxcl4 as a critical driver of myelofibrosis |
Identification Number: |
doi:10.13130/RD_UNIMI/RI3IDJ |
Authoring Entity: |
Capitanio, Daniele (University of Milan) |
Distributor: |
UNIMI Dataverse |
Access Authority: |
Capitanio, Daniele |
Depositor: |
Capitanio, Daniele |
Date of Deposit: |
2023-05-17 |
Holdings Information: |
https://doi.org/10.13130/RD_UNIMI/RI3IDJ |
Study Scope |
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Keywords: |
Medicine, Health and Life Sciences |
Abstract: |
This dataverse include the LC-MS/MS proteomics datasets of changed proteins generated in the study: "Proteomic screening identifies megakaryocyte-derived PF4/Cxcl4 as a critical driver of myelofibrosis" by Daniele Capitanio, Francesca R. Calledda, Vittorio Abbonante, Daniele Cattaneo, Manuela Moriggi, Niccolò Bartalucci, Cristina Bucelli, Delfina Tosi, Umberto Gianelli, Alessandro Maria Vannucchi, Alessandra Iurlo, Cecilia Gelfi, Alessandra Balduini, and Alessandro Malara. Data were generated by LC-ESI-MS/MS with label-free quantitation. Mass spectra were analyzed using MaxQuant software (Max-Planck-Institute of Biochemistry, Munich, Germany, version 1.6.17.0). Statistical analyses were performed using the Perseus software (Max Planck Institute of Biochemistry, Munich, Germany, version 1.6.15.0). For statistical analysis, Student's t-test with a p-value threshold of 0.05 was applied. To exclude the presence of false positives from the analysis, Benjamini–Hochberg false discovery rate test was applied. |
Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Identification Number: |
https://doi.org/10.1182/blood-2023-188967 |
Bibliographic Citation: |
Alessandro Malara, Daniele Capitanio, Francesca Rossella Calledda, Vittorio Abbonante, Daniele Cattaneo, Alessandra Iurlo, Cecilia Gelfi, Alessandra Balduini; "Proteomic Screening Identifies Megakaryocyte Derived PF4/Cxcl4 As a Critical Driver of Myelofibrosis". Blood 2023; 142 (Supplement 1) |
File Description--f137827 |
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File: Bonemarrow proteome.tab |
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Notes: |
UNF:6:kQIHg8sj3vOOhwmvc/OA9w== |
File Description--f137828 |
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File: Megakaryocytes proteome.tab |
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Notes: |
UNF:6:oVj2BjsXpYKZYRJh7tamPg== |
File Description--f137829 |
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File: Platelets proteome.tab |
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Notes: |
UNF:6:AzDH2vPtbMS6ITO2D9yutA== |
List of Variables: |
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Variables |
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f137827 Location: |
Summary Statistics: Mean 23.432580263157895; StDev 2.0668055706875523; Valid 152.0; Max. 32.4258; Min. 18.4124; Variable Format: numeric Notes: UNF:6:oY8L1t/H/4snJTVPa7wNfA== |
f137827 Location: |
Summary Statistics: Valid 152.0; StDev 2.0751209233650036; Min. 18.4264; Mean 23.40931907894737; Max. 32.4786; Variable Format: numeric Notes: UNF:6:g8NyZCxru8fb93MPrttkSA== |
f137827 Location: |
Summary Statistics: Min. 19.6385; Mean 23.544623684210528; Max. 31.2624; StDev 2.165789139991598; Valid 152.0; Variable Format: numeric Notes: UNF:6:13bAMQ9bO03OGJtaQf5UVA== |
f137827 Location: |
Summary Statistics: Valid 152.0; Mean 23.551380263157895; Max. 31.2318; Min. 19.5621; StDev 2.167362024330162; Variable Format: numeric Notes: UNF:6:e2cqQfod/zAPJIZ1LSXkpg== |
f137827 Location: |
Variable Format: character Notes: UNF:6:QaSPTg6pbA/zqaJGNny4Mw== |
f137827 Location: |
Summary Statistics: Max. 56.0; StDev 9.030926975430171; Valid 152.0; Min. 2.0; Mean 9.677631578947373; Variable Format: numeric Notes: UNF:6:7VGBVAr3vSRMk8uJQNKiqw== |
f137827 Location: |
Summary Statistics: Max. 56.0; StDev 8.842999034688448; Valid 152.0; Min. 2.0; Mean 9.243421052631573 Variable Format: numeric Notes: UNF:6:/4YF5SbMA915X67wGjgtiQ== |
f137827 Location: |
Summary Statistics: Mean 8.2171052631579; Max. 56.0; Valid 152.0; Min. 0.0; StDev 8.39024801562389; Variable Format: numeric Notes: UNF:6:ecxVley+DW2qwqxtTZuZxQ== |
f137827 Location: |
Summary Statistics: Max. 95.2; Mean 31.492763157894736; Valid 152.0; Min. 2.6; StDev 16.569021209400816 Variable Format: numeric Notes: UNF:6:sjDrbseSqisKUpxBTb8Tcw== |
f137827 Location: |
Summary Statistics: Mean 30.656578947368423; Min. 1.9; Valid 152.0; Max. 95.2; StDev 16.824704600902606 Variable Format: numeric Notes: UNF:6:Tp8pMAhIVIg1/B//Fu4aLA== |
f137827 Location: |
Summary Statistics: Valid 152.0; StDev 15.74709861960347; Max. 77.5; Mean 27.74671052631579; Min. 0.0 Variable Format: numeric Notes: UNF:6:EGjnt5HOVpJIwrrWfjh/wA== |
f137827 Location: |
Summary Statistics: Mean 53.26435723684211; Max. 274.63; Min. 6.4374; Valid 152.0; StDev 52.0167395288071 Variable Format: numeric Notes: UNF:6:M8xTZTpp5mxpOfpfIJmCsg== |
f137827 Location: |
Summary Statistics: StDev 0.0; Max. 0.0; Min. 0.0; Mean 0.0; Valid 152.0 Variable Format: numeric Notes: UNF:6:wvz02l5hZ6jMwGo7f7dqeA== |
f137827 Location: |
Summary Statistics: Max. 323.31; StDev 86.42919770967181; Mean 88.90986842105264; Valid 152.0; Min. 12.62; Variable Format: numeric Notes: UNF:6:zUaVIrRu3zqFVbJONCUp7g== |
f137827 Location: |
Summary Statistics: Valid 152.0; Mean 3.925871677631578E8; StDev 1.9331345995700874E9; Max. 2.0149E10; Min. 6049700.0 Variable Format: numeric Notes: UNF:6:TlGDldUw4K9XkqCfG33TUA== |
f137827 Location: |
Summary Statistics: Max. 453.0; Valid 152.0; StDev 66.721719890853; Min. 8.0; Mean 50.01315789473684 Variable Format: numeric Notes: UNF:6:fRZATRuMBPZEMymssDhXDQ== |
f137827 Location: |
Summary Statistics: Min. 3.67924E-6; Valid 152.0; StDev 0.00796322012509661; Mean 0.007745272097631579; Max. 0.0302011 Variable Format: numeric Notes: UNF:6:34bX8F7Ebgi9f3Y+RwWxRg== |
f137827 Location: |
Summary Statistics: Min. 8.97734E-4; Valid 152.0; Max. 0.0488018; StDev 0.01200102071720299; Mean 0.018270529763157895 Variable Format: numeric Notes: UNF:6:RAbwtom/IRs+61c2bJxLkQ== |
f137827 Location: |
Summary Statistics: Valid 152.0; Mean 0.1270482677631581; StDev 1.0510042308758236; Max. 4.07449; Min. -4.29254 Variable Format: numeric Notes: UNF:6:zZEp2mGdwdfpLu+FC00lVQ== |
f137827 Location: |
Summary Statistics: Min. -521.339; Mean -9.901448618421064; Max. 115.601; StDev 62.60096808324173; Valid 152.0; Variable Format: numeric Notes: UNF:6:iFS7ItyILoqqHBeehcFZug== |
f137827 Location: |
Variable Format: character Notes: UNF:6:AhMQ8PaCtWlSpqq1T0CRng== |
f137827 Location: |
Variable Format: character Notes: UNF:6:5JX8aWwhmBSY0ZJIaxgH1g== |
f137827 Location: |
Variable Format: character Notes: UNF:6:v2UE/Qgcw5sIaNg/oMrmfA== |
f137827 Location: |
Variable Format: character Notes: UNF:6:ltzKPh4nepdjrklVi554kA== |
f137828 Location: |
Summary Statistics: Min. 20.2442; Valid 51.0; Max. 27.6045; Mean 23.239156862745098; StDev 1.9909598379932127 Variable Format: numeric Notes: UNF:6:b/COsxkC4pvRKO7dOCaDaQ== |
f137828 Location: |
Summary Statistics: Max. 27.4618; Valid 51.0; Min. 19.9241; Mean 23.289649019607843; StDev 2.000979408926794; Variable Format: numeric Notes: UNF:6:0XY8ZOiMy9OvG1BiIREV+A== |
f137828 Location: |
Summary Statistics: Max. 30.2773; StDev 1.8627925116203952; Min. 22.6111; Mean 25.93438431372549; Valid 51.0 Variable Format: numeric Notes: UNF:6:vGSZOYTpvDbyWBm0tnSFNA== |
f137828 Location: |
Summary Statistics: StDev 1.8686585325832215; Mean 25.91623137254902; Min. 22.6231; Valid 51.0; Max. 30.3685 Variable Format: numeric Notes: UNF:6:1aBfKp/TF8lXHN/iomVLzw== |
f137828 Location: |
Variable Format: character Notes: UNF:6:DcTIqyEBu1ZeBmh0wOK4bQ== |
f137828 Location: |
Summary Statistics: Valid 51.0; Mean 17.549019607843135; Max. 89.0; StDev 18.089017359149384; Min. 3.0 Variable Format: numeric Notes: UNF:6:UEuk86TAJpCfnZ36IiuSxw== |
f137828 Location: |
Summary Statistics: Valid 51.0; Mean 17.098039215686278; StDev 18.221146947391414; Min. 3.0; Max. 89.0 Variable Format: numeric Notes: UNF:6:JEcOhvbtaMTSczndxlyJWQ== |
f137828 Location: |
Summary Statistics: Valid 51.0; Min. 1.0; StDev 18.237732917245616; Mean 14.49019607843137; Max. 89.0 Variable Format: numeric Notes: UNF:6:IDpZRqDIJzfQwG/m9n1pyQ== |
f137828 Location: |
Summary Statistics: Mean 43.825490196078434; Valid 51.0; StDev 15.1368403986731; Max. 84.4; Min. 1.1 Variable Format: numeric Notes: UNF:6:qlJ3JpTKtl1VbujDITJsDA== |
f137828 Location: |
Summary Statistics: Valid 51.0; Min. 0.7; Max. 77.6; Mean 42.845098039215685; StDev 15.282817982629906; Variable Format: numeric Notes: UNF:6:MDzAY6JcO5Gwo91mojH+rw== |
f137828 Location: |
Summary Statistics: Min. 0.7; Valid 51.0; Max. 71.9; Mean 36.0843137254902; StDev 17.078868493539257 Variable Format: numeric Notes: UNF:6:vkfQjIfDOSUFVeHJMPIddw== |
f137828 Location: |
Summary Statistics: Max. 503.9; Min. 10.294; StDev 85.64942520460035; Valid 51.0; Mean 62.72862745098039; Variable Format: numeric Notes: UNF:6:uPC8NJvIjhbsLGeCwkY1HQ== |
f137828 Location: |
Summary Statistics: Mean 0.0; Max. 0.0; Valid 51.0; Min. 0.0; StDev 0.0 Variable Format: numeric Notes: UNF:6:6gPOQx1+zbo7w5YK07N2uQ== |
f137828 Location: |
Summary Statistics: Min. 21.722; Max. 323.31; Mean 133.04070588235294; StDev 84.91451209452813; Valid 51.0 Variable Format: numeric Notes: UNF:6:3CMYAWmY8R/xOq2j36ksFQ== |
f137828 Location: |
Summary Statistics: StDev 1.3278674027845623E9; Mean 7.7629068627451E8; Min. 3.7879E7; Valid 51.0; Max. 6.3293E9 Variable Format: numeric Notes: UNF:6:0FvLpHFG+ZTFIC2c2LmX1g== |
f137828 Location: |
Summary Statistics: Valid 51.0; StDev 62.10517328709105; Max. 288.0; Min. 12.0; Mean 74.54901960784314; Variable Format: numeric Notes: UNF:6:w8DmdsvClTjqGUWDYSkv4w== |
f137828 Location: |
Summary Statistics: StDev 0.005017853070107859; Min. 1.40838E-5; Max. 0.0213326; Valid 51.0; Mean 0.003662720547058823 Variable Format: numeric Notes: UNF:6:3zk7kmkRkELyPkDtDvXUCg== |
f137828 Location: |
Summary Statistics: Mean 0.00674321356862745; StDev 0.007183070553843874; Valid 51.0; Max. 0.0305349; Min. 5.18834E-4 Variable Format: numeric Notes: UNF:6:/StspCFF1fR3Pkk8kxmAZA== |
f137828 Location: |
Summary Statistics: Valid 51.0; StDev 1.2084265716175286; Mean 2.6609064705882353; Max. 5.37458; Min. -1.03928; Variable Format: numeric Notes: UNF:6:0xv5STsA3DiA7J8OnrBO6g== |
f137828 Location: |
Summary Statistics: Min. -266.462; StDev 58.39947869700366; Valid 51.0; Max. 8.37715; Mean -48.89189921568627 Variable Format: numeric Notes: UNF:6:cuySGOIrK3cYlHZnADlUtg== |
f137828 Location: |
Variable Format: character Notes: UNF:6:WFDunEs21pD30c0rP1MQBg== |
f137828 Location: |
Variable Format: character Notes: UNF:6:xzsRUdgc9gw7hZtaa2TRXQ== |
f137828 Location: |
Variable Format: character Notes: UNF:6:2KNewRfJhNvFqa2QI1n9yg== |
f137828 Location: |
Variable Format: character Notes: UNF:6:eWrNx8Od/sny58P+SLFQVA== |
f137829 Location: |
Summary Statistics: Min. 20.2771; Mean 24.140583636363637; Valid 110.0; Max. 32.6758; StDev 2.413111051540982; Variable Format: numeric Notes: UNF:6:EFvPHk+iDD2af63AgCW+sg== |
f137829 Location: |
Summary Statistics: Valid 110.0; Mean 24.145446363636363; StDev 2.409192278808617; Min. 20.4012; Max. 32.6569 Variable Format: numeric Notes: UNF:6:/y9jwNc6YzrWi9C5PlO7VA== |
f137829 Location: |
Summary Statistics: Valid 110.0; StDev 2.233079535364274; Min. 20.2486; Max. 32.0712; Mean 24.216641818181817; Variable Format: numeric Notes: UNF:6:0eIt8aRYfPu1z82f5GJGtQ== |
f137829 Location: |
Summary Statistics: Max. 32.0786; Mean 24.209636363636363; StDev 2.2348447759954144; Min. 20.2383; Valid 110.0; Variable Format: numeric Notes: UNF:6:L0YLCKdGFmwkyETjyVNBkA== |
f137829 Location: |
Variable Format: character Notes: UNF:6:TSiBARAe1MOzLfdaJmiyuw== |
f137829 Location: |
Summary Statistics: Mean 11.018181818181818; StDev 11.339612971876944; Min. 2.0; Max. 88.0; Valid 110.0 Variable Format: numeric Notes: UNF:6:Zfy7ka/nNYcq2OwMOZj5Fg== |
f137829 Location: |
Summary Statistics: StDev 11.415132692117464; Min. 2.0; Mean 10.545454545454545; Max. 88.0; Valid 110.0 Variable Format: numeric Notes: UNF:6:vKAHqA4L0dNPuIJMrn4pwA== |
f137829 Location: |
Summary Statistics: Min. 0.0; StDev 11.501042488194829; Valid 110.0; Mean 9.31818181818182; Max. 88.0; Variable Format: numeric Notes: UNF:6:EMeTmklXGd5Xxiz2gFAfIA== |
f137829 Location: |
Summary Statistics: Valid 110.0; Max. 95.2; Mean 28.173636363636362; Min. 3.6; StDev 16.32200449369634 Variable Format: numeric Notes: UNF:6:+WMdkWY5Seq4AuQDUxZdSg== |
f137829 Location: |
Summary Statistics: Mean 27.01090909090909; Max. 95.2; Min. 1.0; StDev 16.599150776633756; Valid 110.0 Variable Format: numeric Notes: UNF:6:V4ypvyXw00QcweYuCz57MA== |
f137829 Location: |
Summary Statistics: StDev 15.23101125729783; Min. 0.0; Mean 23.115454545454547; Valid 110.0; Max. 77.5 Variable Format: numeric Notes: UNF:6:wtwFeJd6dI9DSVGBWJ/WAw== |
f137829 Location: |
Summary Statistics: Min. 8.7279; Max. 280.5; Mean 59.88496272727273; StDev 53.52048232932722; Valid 110.0; Variable Format: numeric Notes: UNF:6:GtM4HRUB7ZaVTlL4Se2xqA== |
f137829 Location: |
Summary Statistics: Min. 0.0; StDev 0.0; Mean 0.0; Valid 110.0; Max. 0.0; Variable Format: numeric Notes: UNF:6:2gonOxP1ek6ET/pNQBkwfA== |
f137829 Location: |
Summary Statistics: Min. 12.697; StDev 89.56540627325467; Valid 110.0; Max. 323.31; Mean 98.04126363636364 Variable Format: numeric Notes: UNF:6:TslWVAl32h5ZwDUrgc8jWA== |
f137829 Location: |
Summary Statistics: Valid 110.0; Mean 6.990227309090904E8; Max. 2.9231E10; StDev 3.0657456296466393E9; Min. 9187500.0 Variable Format: numeric Notes: UNF:6:dxsIQqfpSF/TMb1Iv0wuEw== |
f137829 Location: |
Summary Statistics: Mean 56.4; Valid 110.0; Max. 484.0; StDev 79.05023370959307; Min. 7.0; Variable Format: numeric Notes: UNF:6:xe4btiCN2nfTuw6lYdf5JQ== |
f137829 Location: |
Summary Statistics: StDev 0.008456953551748029; Mean 0.007239718635181819; Valid 110.0; Min. 4.93537E-6; Max. 0.0297767 Variable Format: numeric Notes: UNF:6:bFyr4rL1spftvohzEzidVg== |
f137829 Location: |
Summary Statistics: StDev 0.013698154089534115; Mean 0.01644275779090909; Max. 0.0492669; Min. 8.98237E-4; Valid 110.0 Variable Format: numeric Notes: UNF:6:q5Q5vJE57jwqxQ2d+dRg7Q== |
f137829 Location: |
Summary Statistics: Max. 1.27104; Valid 110.0; StDev 0.7984017989065092; Min. -2.81419; Mean 0.0701211963636366 Variable Format: numeric Notes: UNF:6:FrGmfqG8jMljLJQTd+k6Ig== |
f137829 Location: |
Summary Statistics: StDev 59.65327276387067; Mean -2.8945563636363705; Max. 450.131; Valid 110.0; Min. -155.519 Variable Format: numeric Notes: UNF:6:mMftOczRRpJGjZsEg5CUlw== |
f137829 Location: |
Variable Format: character Notes: UNF:6:WBti8bjbCfqwJNsM6MJPug== |
f137829 Location: |
Variable Format: character Notes: UNF:6:iTkGwYacXqdpBnjPXnUb9A== |
f137829 Location: |
Variable Format: character Notes: UNF:6:kjvP2sTkzPTU/CPJP7bE+Q== |
f137829 Location: |
Variable Format: character Notes: UNF:6:BtkPEevHTW9/mqJ6KYnb5g== |
Label: |
Read me file.pdf |
Notes: |
application/pdf |