Aging is described as a gradual decline in cellular functions, eventually leading to tissue dysfunctions. Thus age is considered a risk factor for several pathologies, e.g. cardiovascular and neurodegenerative diseases. The prevention of age-related diseases and the promotion of health span are primary goals of the current research. An urgent problem to solve is to clarify the molecular mechanisms that drive the “physiological” aging to pathology. In this frame, we propose a multidisciplinary approach that will combine biological and computational integrative approaches to elucidate the non-coding RNA regulatory networks that orchestrate senescence and age-associated processes.